A severe shortage of donor organs available for transplantation in the United States leaves patients suffering from diseased and injured organs with few treatment options. Scientists in the field of tissue engineering apply the principles of cell transplantation, material science, and engineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. Therapeutic cloning, where the nucleus from a donor cell is transferred into an enucleated oocyte in order to extract pluripotent embryonic stem cells, offers a potentially limitless source of cells for tissue engineering applications. The present chapter reviews recent advances that have occurred in therapeutic cloning and tissue engineering and describes applications of these new technologies that may offer novel therapies for patients with end-stage organ failure.
Copyright 2004 Elsevier B.V.
Koh CJ, Atala A. Koh CJ, et al. Curr Top Dev Biol. 2004;60:1-15. doi: 10.1016/S0070-2153(04)60001-9. Curr Top Dev Biol. 2004. PMID: 15094294 Review.
Atala A. Atala A. J Tissue Eng Regen Med. 2007 Mar-Apr;1(2):83-96. doi: 10.1002/term.18. J Tissue Eng Regen Med. 2007. PMID: 18038397 Review.
Atala A, Koh CJ. Atala A, et al. Annu Rev Biomed Eng. 2004;6:27-40. doi: 10.1146/annurev.bioeng.6.012204.115707. Annu Rev Biomed Eng. 2004. PMID: 15255761 Review.
Atala A. Atala A. Curr Opin Biotechnol. 2009 Oct;20(5):575-92. doi: 10.1016/j.copbio.2009.10.003. Epub 2009 Nov 5. Curr Opin Biotechnol. 2009. PMID: 19896823 Review.
Atala A. Atala A. Rejuvenation Res. 2004 Spring;7(1):15-31. doi: 10.1089/154916804323105053. Rejuvenation Res. 2004. PMID: 15256042 Review.
Pino CJ, Humes HD. Pino CJ, et al. Transl Res. 2010 Sep;156(3):161-8. doi: 10.1016/j.trsl.2010.07.005. Epub 2010 Jul 30. Transl Res. 2010. PMID: 20801413 Free PMC article. Review.
Lü S, Li Y, Gao S, Liu S, Wang H, He W, Zhou J, Liu Z, Zhang Y, Lin Q, Duan C, Yang XJ, Wang C. Lü S, et al. J Cell Mol Med. 2010 Dec;14(12):2771-9. doi: 10.1111/j.1582-4934.2010.01112.x. J Cell Mol Med. 2010. PMID: 20586830 Free PMC article.
Wang H, Zhou J, Liu Z, Wang C. Wang H, et al. J Cell Mol Med. 2010 May;14(5):1044-55. doi: 10.1111/j.1582-4934.2010.01046.x. Epub 2010 Feb 27. J Cell Mol Med. 2010. PMID: 20193036 Free PMC article. Review.